Gdspy is a Python module for creation and manipulation of GDSII stream files. Key features for the creation of complex CAD layouts are included: 1. Boolean operations on polygons (AND, OR, NOT, XOR) based on clipping algorithm; 2. Polygon offset (inward and outward rescaling of polygons); and 3. Efficient point-in-polygon solutions for large array sets. Gdspy also includes a simple layout viewer.